Efek Ekstrak Basah Daun Plectranthus amboinicus (L.) Terhadap Produksi Susu, Konsumsi Pakan, Pertumbuhan Bobot Badan Tikus dan Anakan
DOI:
https://doi.org/10.25047/agropross.2021.217Kata Kunci:
efek, ekstrak basah, Plectranthus amboinicus, produksi susu, tikusAbstrak
Insufisiensi laktasi menjadi masalah kesehatan masyarakat karena meningkatkan risiko kesakitan dan kematian bayi. Plectranthus amboinicus (L.) telah dilaporkan efeknya pada peningkatan produksi susu. Dalam beberapa tahun terakhir, metode ekstraksi basah menggunakan pelarut air belum dilaporkan pengaruhnya terhadap produksi susu. Penelitian ini bertujuan untuk 1) mendapatkan dosis ekstrak basah yang efektif terhadap produksi susu, konsumsi pakan, pertumbuhan berat badan tikus dan anakan, 2) memperoleh waktu optimum dalam meningkatkan produksi susu, konsumsi pakan, pertumbuhan berat badan tikus dan anakan, dan 3) mengetahui hubungan produksi susu, konsumsi pakan, pertumbuhan berat badan tikus dan anakan. Penelitian dilakukan di Tropical Biopharmaca Research Center, IPB University, pada Februari 2019 hingga Agustus 2019. Lima belas ekor tikus betina (Rattus norvegicus) galur Sprague-Dawley (SD) dibagi menjadi tiga kelompok. Kelompok pertama sebagai kontrol, kelompok kedua adalah tikus yang diberi dosis 162 mg/kgBB (dosis 1), dan kelompok ketiga adalah tikus yang diberi dosis 324 mg/kgBB (dosis 2). Hasil penelitian menunjukkan bahwa dosis 324 mg/kgBB dapat meningkatkan produksi susu tikus (2,81 ± 0,47 g), pertumbuhan bobot badan anak tikus (18,43 ± 0,21 g), dan konsumsi pakan tikus (18,86 ± 0,18 g) dibandingkan dengan kontrol (masing-masing 1,79 ± 0,89 g, 13,39 ± 0,29 g, 13,14 ± 0,33 g). Pertumbuhan bobot badan tikus pada dosis 2 mengalami penurunan 1,79 ± 0,94 g dibandingkan dengan kelompok kontrol 0,43 ± 0,49 g. Waktu optimal untuk peningkatan produksi susu diperoleh pada hari ke 9-16. Peningkatan produksi susu berkorelasi positif dengan pertumbuhan bobot badan anak tikus dan konsumsi pakan tikus. Di sisi lain, produksi susu berkorelasi negatif dengan pertumbuhan berat badan tikus.
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Referensi
Aguiar, J. J. S., Sousa, C. P. B., Araruna, M. K. A., Silva, M. K. N., Portelo, A. C., Lopes, J. C., Carvalho, V. R. A., Figueredo, F. G., Bitu, V. C. N., Coutinho, H. D. M., Miranda, T. A. S., & Matias, E. F. F. (2015). Antibacterial and modifying-antibiotic activities of the essential oils of Ocimum gratissimum L. and Plectranthus amboinicus L. European Journal of Integrative Medicine, 7(2), 151–156. https://doi.org/10.1016/j.eujim.2014.10.005
Akagawa, S., Tsuji, S., Onuma, C., Akagawa, Y., Yamaguchi, T., Yamagishi, M., Yamanouchi, S., Kimata, T., Sekiya, S., Ohashi, A., Hashiyada, M., Akane, A., & Kaneko, K. (2019). Effect of Delivery Mode and Nutrition on Gut Microbiota in Neonates. Annals of Nutrition and Metabolism, 74(2), 132–139. https://doi.org/10.1159/000496427
Belfort, M. B., Anderson, P. J., Nowak, V. A., Lee, K. J., Molesworth, C., Thompson, D. K., Doyle, L. W., & Inder, T. E. (2016). Breast Milk Feeding, Brain Development, and Neurocognitive Outcomes: A 7-Year Longitudinal Study in Infants Born at Less Than 30 Weeks’ Gestation. The Journal of Pediatrics, 177, 133-139.e1. https://doi.org/10.1016/j.jpeds.2016.06.045
Belfort, M. B., Rifas-Shiman, S. L., Kleinman, K. P., Guthrie, L. B., Bellinger, D. C., Taveras, E. M., Gillman, M. W., & Oken, E. (2013). Infant Feeding and Childhood Cognition at Ages 3 and 7 Years: Effects of Breastfeeding Duration and Exclusivity. JAMA Pediatrics, 167(9), 836. https://doi.org/10.1001/jamapediatrics.2013.455
Bhatt, P., Joseph, G. S., Negi, P. S., & Varadaraj, M. C. (2013). Chemical Composition and Nutraceutical Potential of Indian Borage ( Plectranthus amboinicus ) Stem Extract. Journal of Chemistry, 2013, 1–7. https://doi.org/10.1155/2013/320329
Bhattacharya, R., Dev, K., & Sourirajan, A. (2021). Antiviral activity of bioactive phytocompounds against coronavirus: An update. Journal of Virological Methods, 290, 114070. https://doi.org/10.1016/j.jviromet.2021.114070
Brandao, E. M., Brandão, P. H. D. M., Souza, I. A., Paiva, G. S., de C. Carvalho, M., & Lacerda, C. M. (2013). Antineoplasic Effect of Aqueous Extract of Plectranthus Amboinicus in Ehrlich Ascites Carcinoma. Journal of Cancer, 4(7), 573–576. https://doi.org/10.7150/jca.6730
Chang, Y.-L., Yao, Y.-T., Wang, N.-S., & Lee, Y.-C. (1998). Segmental Necrosis of Small Bronchi after Prolonged Intakes of Sauropus androgynus in Taiwan. American Journal of Respiratory and Critical Care Medicine, 157(2), 594–598. https://doi.org/10.1164/ajrccm.157.2.9704040
Chen, Y.-S., Yu, H.-M., Shie, J.-J., Cheng, T.-J. R., Wu, C.-Y., Fang, J.-M., & Wong, C.-H. (2014). Chemical constituents of Plectranthus amboinicus and the synthetic analogs possessing anti-inflammatory activity. Bioorganic & Medicinal Chemistry, 22(5), 1766–1772. https://doi.org/10.1016/j.bmc.2014.01.009
Damanik, R., Ao, M. L. W., & Wattanapenpaiboon, N. (2006). Lactagogue effects of Torbangun, a Bataknese traditional cuisine. Asia Pac J Clin Nutr, 15(2), 267–274.
Damanik, R. M., Kustiyah, L., Hanafi, M., & Iwansyah, A. C. (2017). Evaluation Lactogenic Activity of Ethyl Acetate Fraction of Torbangun ( Coleus amboinicus L.) Leaves. IOP Conference Series: Earth and Environmental Science, 101, 012007. https://doi.org/10.1088/1755-1315/101/1/012007
Desai, G., Sunil Kumar, G., Manoj, L., Gokul, G. R., Beena, K. V., Thennarasu, K., & Jaisoorya, T. S. (2019). Prevalence & correlates of chronic perinatal pain – a study from India. Journal of Psychosomatic Obstetrics & Gynecology, 40(2), 91–96. https://doi.org/10.1080/0167482X.2017.1405258
El-hawary, S. S., El-sofany, R. H., Abdel-Monem, A. R., Ashour, R. S., & Sleem, A. A. (2012). Polyphenolics content and biological activity of Plectranthus amboinicus (Lour.) spreng growing in Egypt (Lamiaceae). Pharmacognosy Journal, 4(32), 45–54. https://doi.org/10.5530/pj.2012.32.9
Fati, N., Irda, I., & Syukriani, D. (2014). Using of Bangun-Bangun Leafs (Coleus Amboinicus, L) on Red Sugar Block to Upgrading Milk Production of Frisian Holstein. International Journal on Advanced Science, Engineering and Information Technology, 4(2), 84. https://doi.org/10.18517/ijaseit.4.2.374
Foidart, J. (1998). Estradiol and Progesterone Regulate the Proliferation of Human Breast Epithelial Cells. Fertility and Sterility, 69(5), 963–969. https://doi.org/10.1016/S0015-0282(98)00042-9
Govindaraju, S., & Arulselvi, P. I. (2018). Characterization of Coleus aromaticus essential oil and its major constituent carvacrol for in vitro antidiabetic and antiproliferative activities. Journal of Herbs, Spices & Medicinal Plants, 24(1), 37–51. https://doi.org/10.1080/10496475.2017.1369483
Grzeskowiak, L. E., Wlodek, M. E., & Geddes, D. T. (2019). What Evidence Do We Have for Pharmaceutical Galactagogues in the Treatment of Lactation Insufficiency?—A Narrative Review. Nutrients, 11(5), 974. https://doi.org/10.3390/nu11050974
Guo, X., Diao, Q., Wang, Y., Tu, Y., Deng, K., Wang, X., Fu, T., & Yan, G. (2012). The Effect of Administration of Rutin on Plasma Levels of Estrogen, Prolactin, Growth Hormone and Gene Expression of Their Receptors in Mammary Glands in Ovariectomized Rats. Journal of Integrative Agriculture, 11(10), 1700–1706. https://doi.org/10.1016/S2095-3119(12)60173-7
He, S., & Xia, H. (2019). The relationship between neutrophil-lymphocyte ratio and onset of lactation among postpartum women: A prospective observational cohort study. International Journal of Nursing Studies, 97, 55–62. https://doi.org/10.1016/j.ijnurstu.2019.05.005
Horta, B. L., Hartwig, F. P., & Victora, C. G. (2018). Breastfeeding and intelligence in adulthood: Due to genetic confounding? The Lancet Global Health, 6(12), e1276–e1277. https://doi.org/10.1016/S2214-109X(18)30371-1
Iwansyah, A. C., Damanik, M. R. M., Kustiyah, L., & Hanafi, M. (2017). Potensi Fraksi Etil Asetat Daun Torbangun (Coleus amboinicus L.) dalam Meningkatkan Produksi Susu, Bobot Badan Tikus, dan Anak Tikus. Jurnal Gizi dan Pangan, 12(1), 61–68. https://doi.org/10.25182/jgp.2017.12.1.61-68
Kociszewska-Najman, B., Sibanda, E., Radomska-Leśniewska, D. M., Taradaj, K., Kociołek, P., Ginda, T., Gruszfeld, M., Jankowska-Steifer, E., Pietrzak, B., Wielgoś, M., & Malejczyk, J. (2020). Does Caesarean Section or Preterm Delivery Influence TGF-β2 Concentrations in Human Colostrum? Nutrients, 12(4), 1095. https://doi.org/10.3390/nu12041095
Kumari, B. P., Sujatha, D., Chand, C. G., Divya, K., Malleswari, I., & Ranganayakulu, D. (2012). Evaluation of antiepileptic activity and probable mechanism of action of Coleus amboinicus in MES and PTZ models. Journal of Pharmacy Research, 3, 6.
Li, D., Jiang, Y., Ma, X., Li, Q., Chu, X., Zhong, W., Deng, X., & Yang, X. (2021). The effect of pestle acupuncture for patients with lactation insufficiency after cesarean section: Study protocol for a randomized controlled trial. Medicine, 100(3), e23808. https://doi.org/10.1097/MD.0000000000023808
Mahmood, A., Omar, M. N., & Ngah, N. (2012). Galactagogue effects of Musa x paradisiaca flower extract on lactating rats. Asian Pacific Journal of Tropical Medicine, 5(11), 882–886. https://doi.org/10.1016/S1995-7645(12)60164-3
Mohanty, I., Senapati, M. R., Jena, D., & Behera, P. C. (2014). Ethnoveterinary importance of herbal galactogogues—A review. Veterinary World, 7(5), 325–330. https://doi.org/10.14202/vetworld.2014.325-330
Nengsih, R. F., Mustika, A. A., & Andriyanto. (2020). Evaluasi Gambaran Darah dan Marker Stres (Rasio H/L) Ayam Pedaging yang Diberi Daun Bangun-Bangun selama 28 Hari. Acta Veterinaria Indonesiana, 8(2), 9–15.
Pillai, P. G., Suresh, P., Aggarwal, G., Doshi, G., & Bhatia, V. (2011). Plectranthus amboinicus (Lour) Spreng. Journal of Applied Pharmaceutical Science, 1(2), 75–81.
Purwantari, N. D., & Sutedi, E. (2011). Pengaruh Interval Potong terhadap Produktivitas dan Kualitas Tanaman Bangun-Bangun (Coleus amboinicus L.) sebagai Komoditas Harapan Pakan Ternak. JITV, 16(4), 288–293.
Rumetor, S. D. (2008). Suplementasi Daun Bangun-Bangun (Coleus amboinicus Lour) dan Zinc—Vitamin E dalam Ransum untuk Memperbaiki Metabolisme dan Produksi Susu Kambing Peranakan Etawah. 188.
Selvakumar, P., naveena, B. E., & prakash, S. D. (2012). Studies on the antidandruff activity of the essential oil of coleus amboinicus and eucalyptus globulus. Asian Pacific Journal of Tropical Disease, 2, S715–S719. https://doi.org/10.1016/S2222-1808(12)60250-3
Shubha, J. R., & Bhatt, P. (2015). Plectranthus amboinicus leaves stimulate growth of probiotic L. plantarum: Evidence for ethnobotanical use in diarrhea. Journal of Ethnopharmacology, 166, 220–227. https://doi.org/10.1016/j.jep.2015.02.055
Silva, O. L. de O., Rea, M. F., Sarti, F. M., & Buccini, G. (2020). Cost-effectiveness analysis of Baby-Friendly Hospital Initiative in promotion of breast-feeding and reduction of late neonatal infant mortality in Brazil. Public Health Nutrition, 1–11. https://doi.org/10.1017/S1368980020001871
Sultana, A., Rahman, K. U. R., & Manjula, S. (2013). Clinical Update and Treatment of Lactation Insufficiency. Medical Journal of Islamic World Academy of Sciences, 21(1), 19–28. https://doi.org/10.12816/0000207
Suprayogi, A., ter Meulen, U., Ungerer, T., Manalu, W. (2001). Population of secretory cells and synthetic activities in mammary gland of lactating sheep after consuming Sauropus androgynus (L.) Merr. leaves. Indones J Trop Agric, 10(1), 1-3.
Suprayogi, A., Kusumorini, N., & Arita, S. E. D. (2015). Fraksi Heksan Daun Katuk Sebagai Obat Untuk Memperbaiki Produksi Susu, Penampilan Induk, dan Anak Tikus. Jurnal Veteriner, 16(1), 88–95.
Suresh, S., Muthukrishnan, L., Vennila, S., K., G., J., A. L., Paiman, S., Faruq, M., Al-Lohedan, H. A., Akbarzadeh, O., & Oh, W. C. (2020). Mechanistic anticarcinogenic efficacy of phytofabricated gold nanoparticles on human lung adenocarcinoma cells. Journal of Experimental Nanoscience, 15(1), 160–173. https://doi.org/10.1080/17458080.2020.1761014
Tabares, F., Bedoya Jaramillo, J. V., & Ruiz-Cortés, Z. T. (2014). Pharmacological Overview of Galactogogues. Veterinary Medicine International, 2014, 1–20. https://doi.org/10.1155/2014/602894
Takahashi, T. (2021). Sensory Stimulation of Oxytocin Release Is Associated With Stress Management and Maternal Care. Frontiers in Psychology, 11, 588068. https://doi.org/10.3389/fpsyg.2020.588068
Wall, E. H., & McFadden, T. B. (2012). Triennial Lactation Symposium: A local affair: How the mammary gland adapts to changes in milking frequency1,2. Journal of Animal Science, 90(5), 1695–1707. https://doi.org/10.2527/jas.2011-4790
Wibisono, K., Aisyah, S. I., Suhesti, S., & Nurcholis, W. (2019). Optimization of Total Flavonoids Extraction and Α-Glucosidase Inhibitory Activity from Plectranthus amboinicus (Lour.) Spreng. Leaves using the Simplex-Centroid Design. Molekul, 14(2), 84. https://doi.org/10.20884/1.jm.2019.14.2.497
Yanza, Y. R., Szumacher-Strabel, M., Bryszak, M., Gao, M., Kolodziejski, P., Stochmal, A., Slusarczyk, S., Patra, A. K., & Cieslak, A. (2018). Coleus amboinicus (Lour.) leaves as a modulator of ruminal methanogenesis and biohydrogenation in vitro. Journal of Animal Science. https://doi.org/10.1093/jas/sky321
Yu, S.-F., Chen, T.-M., & Chen, Y.-H. (2007). Apoptosis and Necrosis are Involved in the Toxicity of Sauropus androgynus in an In Vitro Study. Journal of the Formosan Medical Association, 106(7), 537–547. https://doi.org/10.1016/S0929-6646(07)60004-7
Zhang, B., Wijesundara, N. M., Abbey, Lord, & Rupasinghe, H. P. V. (2017). Growing medium amendments effect on growth, secondary metabolites and anti-streptococcal activity of two species of Plectranthus. Journal of Applied Research on Medicinal and Aromatic Plants, 5, 53–59. https://doi.org/10.1016/j.jarmap.2016.11.001
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